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Jamaica Scientific Research Institute
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Conventional Treatments for GERD and Peptic Ulcers

There are three conventional types of treatment available for GERD and Peptic ulcers, viz Lifestyle changes, Medications and Surgery.

Lifestyle changes

Modification of one’s lifestyle can to help treat symptoms. Changes in diet by problem foods such as oily and/or spicy meals, acidic fruits, sweets, caffeine among others and making changes to routine before you go to sleep have been shown to provide some relief.

Also sleeping on the left side can help to reduce nighttime reflux episodes in patients.


Over-the-counter treatments for GERD such as antacids that neutralize stomach acid are first used to control heartburn but while these may provide quick relief, they won't heal an inflamed oesophagus damaged by stomach acid.

For Peptic Ulcers, treatment involves a combination of medications to kill the H. pylori bacteria (if present), and reduce acid levels in the stomach. This strategy allows the ulcer to heal and reduces the chance it will come back.

Other medications are shown in the table below and include Proton Pump Inhibitors (PPIs), Histamine H-2 Blockers, Prokinetic agents, Adenylate cyclase inhibitors, cytoprotective agents and anti-biotics.


Most incidences of GERD and Peptic Ulcers can be controlled through medications. In situations where symptoms do not go away with lifestyle changes and drugs, different surgical procedures may be done including:

  • Surgery to reinforce the lower esophageal sphincter
  • Surgery to create a barrier preventing the backup of stomach acid
  • Surgery to strengthen the lower esophageal sphincter (Linx)

Table below illustrates the Types of Medications used in the treatment of GERD and Peptic Ulcers. This list is not exhaustive.

Click here to view the chemical structures page.

Drug ClassActions Common Side Effects
AntacidsReduce gastric acidity
  • Diarrhea
  • Constipation
 Proton pump inhibitors

(lansoprazole, omeprazole and esomeprazole)

Stop or reduce acid secretion at the source of acid production, i.e., the proton pump. This gives the damaged oesophageal tissue time to heal
  • Constipation
  • Nausea
  • Headache
  • Dizziness
  • Dry mouth
  • Rash
Histamine  H-2 Blockers

(cimetidine, famotidine, nizatidine or ranitidine)

Lower the amount of acid released in the stomach.

H2-receptorblockers don't act as quickly as antacids, but they provide longer relief.
  • Headache (may be severe)
  • Drowsiness, dizziness
  • Sleep problems (insomnia)
  • Decreased sex drive, impotence, or difficulty having an orgasm
  • Swollen or tender breasts
  • Nausea, vomiting, stomach pain
  • Diarrhoea or constipation

Prokinetic agents

(Metoclopramide, Itopride)

Help the stomach empty more rapidly and help tighten the valve between the stomach and the esophagus.
  • Fatigue
  • Depression
  • Anxiety
  • Back or chest pain
  • Increased salivation
  • Constipation
 Adenylate cyclase inhibitors


Decrease Proton pump activity (not as effective as PPIs)
  •  Diarrhoea
Cyto-protective agents


Reacts with hydrochloric acid in the stomach to form a cross-linking, viscous, paste-like material.
It also attaches to proteins on the surface of ulcers.
These effects serve as protective barriers at the ulcer surface.

  • Constipation
  • Bezoar
  • Flatulence

Two or more different types used

(clarithromycin, amoxicillin, tetracycline or metronidazole)

Kills bacteria or stop bacterial growth.
  • Diarrhoea
  • Constipation
  • Nausea
  • Dry mouth
  • Rash

For a full profile on a drug you may be taking, visit Drugs.com or Rxlist.com and simply enter the name.

If you have tried one or more conventional therapies for this disorder, or even one or more alternative therapies including herbs, but yet still find that they have made little difference and that you are still suffering, try JaSciRes.

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